Product ID:TRYPSIN, BOVINE PANCREAS, 6502
MSDS Date:11/11/1998
FSC:6550
NIIN:00N092496
Status Code:A
MSDS Number: CJSPB

Emergency Phone: 202-783-7616 (INTERNATL)

Info Phone: 800-854-3417; 619-450-5558

Cage: 29089

Telephone: 619-450-5558; 800-854-3417

Cage: 29089

TRYPSIN

CAS: 9002-07-7

RTECS: YN5075000

LD50 LC50 Mixture:LD50:(ORAL,RAT) >5 G/KG & TOX INFO
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:MAY BE HARMFUL BY INGESTION,
INHALATION OR ABSORPTION THROUGH SKIN. MATERIAL CAUSES SEVERE
IRRITATION TO THE EYES, SKIN, MUCOUS MEMBRANES, AND THE UPPER
RESPIRATORY TRACT. PROLONGED OR REPEATED EXPOSU RE MAY CAUSE
ALLERGIC REACTIONS IN SENSITIVE INDIVIDUALS.
Effects of Overexposure:SEE HEALTH HAZARDS.

First Aid:SKIN: WASH IMMEDIATELY WITH COPIOUS AMOUNTS OF WATER FOR AT
LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND SHOES AND WASH
BEFORE WEARING. CONSULT MD. EYES: FLUSH IMMEDIATELY WITH COPIOUS
AMOUNTS O F WATER FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING
BY SEPARATING EYELIDS WITH FINGERS. CONSULT MD. INHALATION: REMOVE
TO FRESH AIR AND MONITOR BREATHING. IF BREATHING BECOMES DIFFICULT,
GIVE OX YGEN AND CONSULT MD. IF BREATHING STOPS, GIVE ARTIFICIAL
RESPIRATION AND CONSULT MD. INGESTION: WASH MOUTH OUT WITH WATER
AND CONSULT LOCAL POISON CENTER AND MD.

Extinguishing Media:DRY CHEMICAL POWDER, CARBON DIOXIDE, WATER SPRAY,
ALCOHOL OR POLYMER FOAM.
Fire Fighting Procedures:USE NIOSH APPROVED SCBA AND FULL PROTECTIVE
EQUIPMENT .
Unusual Fire/Explosion Hazard:UPON THERMAL DECOMPOSITION, IT MAY EMIT
TOXIC GASES.

Spill Release Procedures:EVACUATE AREA. WEAR A NIOSH APPROVED
RESPIRATOR, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS AND HEAVY RUBBER
GLOVES. SWEEP UP AND PLACE IN A SUITABLE CONTAINER. AVOID RAISING
DUST. HOLD FOR APPROPRIATE DIS POSAL. WASH SPILL SITE AND VENTILATE
AREA AFTER MATERIAL PICKUP IS COMPLETE.

Handling and Storage Precautions:STORE IN A TIGHTLY CLOSED CONTAINER IN
A (+4C) REFRIGERATOR. PROTECT FROM MOISTURE. MATERIAL IS HARMFUL
AND AN IRRITANT. MATERIAL MAY CAUSE SENSITIZATION. AVOID CONTACT
WITH MATERIAL. AVOID PROLONGED OR REPEATED EXPOSURE. DO NOT
BREATHE DUST. AVOID CONTACT WITH SKIN AND EYES.
Other Precautions:MAY CAUSE SENSITIZATION BY INHALATION AND SKIN
CONTACT. IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL
ADVICE IMMEDIATELY. MATERIAL SHOULD ONLY BE HANDLED BY QUALIFIED,
EXPERIENCED PROFESSION ALS.

Respiratory Protection:USE A NIOSH APPROVED RESPIRATOR.
Ventilation:HANDLE IN A CHEMICAL FUME HOOD WITH ADEQUATE VENTILATION.
Protective Gloves:CHEMICAL RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES & FULL LENGTH
FACESHIELD .
Other Protective Equipment:ANSI APPROVED EYE WASH & DELUGE SHOWER .
WEAR SUITABLE PROTECTIVE CLOTHING.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING MATERIAL.
Supplemental Safety and Health
MFR'S INFO: MFR'S FAX #: (619) 452-3552; MFR'S INFO ON INGS: MOLECULAR
WEIGHT: 23, 281. -- PHYSICAL AND CHEMICAL PROPERTIES: SOLUBILITY:
SOLUBLE IN HCL, NEUTRAL BUFFERS.

Solubility in Water:SOLUBLE & SEE SUPP DATA
Appearance and Odor:SALT-FREE SOLID.

Stability Indicator/Materials to Avoid:YES
NOT APPLICABLE.
Stability Condition to Avoid:STABLE UNDER NORMAL HANDLING PROCEDURES.
Hazardous Decomposition Products:UPON THERMAL DECOMPOSITION, MAY EMIT
TOXIC GASES INCLUDING CARBON MONOXIDE AND CARBON DIOXIDE.

Waste Disposal Methods:COUNTRY, FEDERAL, STATE & LOCAL REGS ARE VARIED
AND CHANGE FREQUENTLY. FOR THIS REASON, MFR RECOMMENDS THAT YOU
CONT YOUR LOCAL DEPARTMENT OF HEALTH SERVICES FOR INFO ON THE
DISPOSAL OF THIS PROD/ARRA NGE FOR DISPOSAL BY A LICENSED DISPOSAL
COMPANY. DISPOSE OF IN ACCORDANCE WITH FEDERAL, STATE AND L OCAL
REGULATIONS .

Toxicological Information:TOX DATA & REFERENCES: LD50:(ORAL,RAT) >5
G/KG 1990; LD50:(ORAL,MUS) 1450 MG/KG; LD50:(IPR,RAT) >51 MG/KG
1990; LD50:(IVN,MUS) 11,100 UG/KG; LD50:(IVN,RBT) 2200 UG/KG;
LD50:(IMS,RAT) 200 UG/KG 1990; L D50:(IMS,MUS) 105 MG/KG 1990.
"DRUGS IN JAPAN (ETHICAL DRUGS)". -, 744. LD50:(IPR,MUS) 100 MG/M3
1982; LD50:(IVN,RAT) 36 MG/KG 1982. "FARMAKOLOGIYA I TOKSIKOLOGIYA
(MOSCOW)". 45(6), 78. GENETIC DATA & REFERENCES: FBR; HAM; DOSE:
100 PPM DNA DMG 1970. "COLLECTION OF PAPERS PRESENTED AT ANNUAL
SYMPOSIUM ON FUNDAMENTAL CANCER RESEARCH". 23, 346. REFER TO
(RTECS) FOR DEFINITION OF ABBREVIATIONS USED I N TEXT & FOR ADDNL
INFO. (OTHER INFO)

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:NO INFORMATION AVAILABLE.

Transport Information:UN NUMBER: N/A. PROPER SHIPPING NAME: N/A. IATA
CLASS: N/A. IATA PACKING GROUP: N/A.

Federal Regulatory Information:REGULATORY INFORMATION: XI, XN. RISK
PHRASES: R20/21/22: HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND
IF SWALLOWED. R36/37/38: IRRITATING TO EYES, RESPIRATORY SYSTEM AND
SKIN. R42: MAY CAUSE SENSIT IZATION BY INHALATION AND SKIN CONTACT.
SAFETY PHRASES: S22: DO NOT BREATHE DUST. S24/25: AVOID CONTACT
WITH SKIN AND EYES. S26: IN CASE OF CONTACT WITH EYES, RINSE
IMMEDIATELY WITH PLENTY OF WATER AN D SEEK MEDICAL ADVICE.
S36/37/39: WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
PROTECTION. S45:IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK
MEDICAL ADVICE IMMEDIATELY.
State Regulatory Information: